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Synthetic neoantigens formed by proteasome-resistant modification of KRAS G12C peptides with covalent inhibitors are loaded onto HLAs as so-called haptenated peptides or p* (peptides still carrying the covalent inhibitor) and presented as p*MHCs on the cancer cell surface as homogeneously modified epitopes

Human reproduction (Oxford, England)

Additionally, people who regularly take vitamin B-12 injections or supplements gain fewer pounds in ten years than those who do not take the vitamin

Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1

These binderscommonly including mineral clays, activated charcoal, and silica-based compoundsreduce enterohepatic recirculation and support Phase 3 elimination through regular bowel movements