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Q4: Are there any side effects associated with these treatments

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Unlike full-length human growth hormone, none of them seem to have any effect on blood sugar levels, insulin sensitivity or other hormonal pathways, this lessens the risk of major metabolic side effects

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Somewhat contradictory to the observations in animals, Savage et al (56) reported 27 prepubertal children with severe GH insensitivity syndrome (GHIS or Severe Primary IGF Deficiency (SPIGFD)) to have a median (range) birth weight SDS of -0.72 (1.75 - (-3.29)) and birth length SDS of -1.59 (0.63 - (-3.63))