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IGFBP-2 actions are linked to insulin, although only in cases of hyperinsulinemia [173] where it seems to play a role on adipocyte autocrine control [174]

Reactive oxygen species (ROS), which include hydrogen peroxide (H2O2), superoxide radical (O2-), hydroxyl radical (OH), and singlet oxygen (1O2), are harmful byproducts of basic metabolic processes in living organisms [9, 10]
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