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Description
This matters more for injectables than topicals

Annals of the New York Academy of Sciences, 1112(1), 112

20 BeyerT.HerrmannM.ReiserC.BertlingW.HessJ

Current protocols draw from animal studies, practitioner experience, and a small number of early-stage human pilots

It must survive stomach acid and digestive enzymes, then be absorbed through the intestinal lining into the bloodstream