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Additionally, a broad spectrum of nonmotor symptoms is commonly observed, such as sleep disturbances, constipation, depression, olfactory dysfunction, and cognitive impairment [4, 5, 6, 7]

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However, the liver may become a glutamine-consuming site, and tissues, such as muscle tissue, may present reduced glutamine synthesis under certain conditions, such as reduced carbohydrate [16] and/or amino acid [17] intake, high catabolic situations, and/or diseases and stress [5]
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