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Endocr J 2023;70:86774.ArticlePubMed 7

With chronic opiate use, the locus coeruleus adapts by increasing its baseline activity
Different tissues have very different receptor densities

This was held true when adjusted for other known ARDS risk factors (aspiration, chemotherapy, high-risk surgery, pancreatitis, sepsis, shock)

A randomized, controlled, clinical pilot study assessing the analgesic effect of morphine applied topically onto split-thickness skin wounds
