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MAPK signaling serves as a potential pathway for autophagy regulation and can activate autophagy as a downstream effector of reactive oxygen species [64, 65]

Although several guidelines do not recommend the use of antioxidants (including PTX) in the treatment of PD, many therapeutic experiences have been published with the use of PTX, either alone or in combination with other antioxidant and non-antioxidant therapies [27,70,71,72]

Tie2 activation contributes to hemangiogenic regeneration after myelosuppression

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