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Exploration of cytochrome P450 inhibition mediated drug-drug interaction potential of kratom alkaloids

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By stimulating the white-to-brown conversion hormonally, we observed that a rapid drop of GSH concentration and decreased GSH/GSSG ratio accompany the up-regulation of brown-related genes and that such an event is significantly blunted by supplementing adipocytes with GSH ester

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Tschopp J

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