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Gallbladder disease : Tirzepatide is associated with increased risk of gallbladder disease, including cholelithiasis and cholecystitis

Madhusoodanan, V., Patel, P., Lima, T

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We now demonstrate that targeting CD38 with heavy-chain antibodies that selectively inhibit NAD glycohydrolase activity without inducing cell death or global CD38 blockade will boost tissue NAD + and precursor levels and sirtuin activity, reduce cellular senescence and mitigate fibrosis and inflammation in multiple organs