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Neuropeptide Y (NPY)/ Agouti-related peptide (AgRP) neurons are the first-order orexigenic neurons

Therefore, ACTH pulsatile secretion plays a primary role in the gene regulation of critical enzymes and receptors involved in cortisol synthesis and secretion by the adrenal gland

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At the same time, its cytoplasmic domain connects to the actin cytoskeleton and functions to organize it, affecting the formation of the stress fibers and focal adhesion complexes, which are essential for cell migration and the development of fibrosis [52,53]