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Institutional Review Board Statement This research was approved by the local Ethics Committee (Approval date: 02/11/22017

10.1073/pnas.0810199105 303 WolfsonR

If bowel transit and microbiome balance are poor, hormones recirculate improperly, metabolic inflammation increases, and many interventions fail to stick
Upon intrinsic factor-cobalamin binding to cubilin, the complex is endocytosed

Although administration of some antioxidants may suppress neurodegeneration, no clinically apparent efficacy has been demonstrated yet
