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Studies in Crat knockout mice demonstrated that CrAT deficiency leads to abnormal fuel selection, which results in a perturbation of glucose homeostasis and suggest that deficits in CrAT activity might contribute to diet-induced metabolic inflexibility by exacerbating the Randle glucose-fatty acid cycle 66
Therefore, carnitine excretion by the kidney is usually very low
When used strategically, it can enhance energy utilization, training performance, and overall consistency during a fat loss phase
doi: 10.1046/j.1432-1327.1999.00524.x
To use fat for energy it requires oxygen, so this makes sense
