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Within each complex, the miRNA pairs to target RNAs, and AGO provides effector function while also protecting the miRNA from cellular nucleases 2,3,4,5
(PubMed) Heinisch BB, Francesconi M, Mittermayer F, et al
Immune Dysfunction in Irritable Bowel Syndrome: A Role for T Cells
In addition, EET analogues significantly induce GSK-3 inactivation, attenuate inflammatory cell infiltration and reduce the development of kidney tubular apoptosis (Hoff et al., 2019)
The significance of ApoE4 is such that ApoE4 +/+ carriers could represent a distinct genetic AD variant based on very high penetrance (Fortea et al., 2024)
