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Other distinct mitochondrial sites associated with substrate oxidation and oxidative phosphorylation leak electrons to oxygen to produce superoxide or hydrogen peroxide, and these include oxoacid dehydrogenase complexes that shuttle electrons to NAD + [6]

10.1016/j.intimp.2023.110153 201 WangB.WangY.ZhangJ.HuC.JiangJ.LiY.et al (2023c)

The process of acetylation is catalyzed by acetyltransferases and can be reversed by deacetylases, thereby maintaining a critical balance essential for cellular homeostasis and the regulation of normal biological functions [53]

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Finally, supplementing NaGYY, the sodium salt of GYY4137, a slow-releasing H 2 S donor, restored sulfhydration and ameliorated motor and cognitive deficits in the 3xTg-AD mice (Giovinazzo et al., Figure 2 Therapeutic Avenues Analysis of clinical trials conducted so far, reveal a preference for non-amyloid targets, which include therapeutics targeting inflammation, synapse and neuronal protection, vascular factors, neurogenesis, and epigenetic modifications (Cummings et al., 2 S regulates a wide array of neuroprotective processes, therapies, and interventions involving either the use of H 2 S delivering drugs or agents which stimulate its production are gaining importance