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These actions result in decreased circulating serotonin at the CTZ level, reducing symptoms of nausea and vomiting in affected patients.67, 68 Ondansetron is metabolized in the liver by CYP3A4, CYP1A2, and CYP2D6 and is excreted renally.69 Despite its wide use in CVS, there is a lack of clinical trials of 5HT 3 antagonists in this condition

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