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doi: 10.1016/j.nbd.2022.105772

2021;9(08):e3753

Muscle Mass and Body Composition Research in growth hormone-deficient and intact animal models showed effects on lean body mass: 15.3% increase in body weight in GH-deficient mice treated with ipamorelin over 9 weeks Enhanced protein synthesis and nitrogen retention in skeletal muscle tissue Dose-dependent effects on body weight gain and lean mass accretion Preserved muscle mass during catabolic conditions in experimental models Studies using DEXA scanning confirmed increases in lean tissue mass with corresponding reductions in fat mass percentage

Nature 512 , 4953 (2014)

Then NFB can translocate to the nucleus and induce the expression of target genes