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Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and prostaglandin I synthase activity

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Phosphorylated STAT3 is translocated from the cytoplasm into the nucleus, where it acts as a transcription factor to regulate the expression of its target genes, including suppressor of cytokine signaling 3 (SOCS3) and neuropeptides [27, 28]

SY: Investigation, Methodology, Writing original draft, Writing review & editing