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Depolarization of endothelial cell membranes induces ROS production and subsequent inflammation ( 3.2.2 Application of PCLS to measure calcium overload Intracellular calcium overload is one of the main pathological mechanism of lung IRI ( 2+ levels in lung slices, a previous study showed that Ca 2+ oscillations are essential for maintaining the contractile state of the airway smooth muscle cells and, thus, the airway contraction ( 2+ in PCLS ( 2+ signaling has been possible by combining the PCLS with real-time confocal or two-photon microscopy ( ex vivo PCLS to decipher the relevance of calcium and ion-mediated signaling in post-LTx IRI

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Polyphenols intervention is an effective strategy to ameliorate inflammatory bowel disease: a systematic review and meta-analysis