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Long-term follow-up is needed to assess durability of benefits and identify any delayed adverse effects

These authors analyzed protein levels in raw plasma from patients whose cognitive status changed from VCD to healed, and vice versa, between recruitment and the six-month follow-up, while the present study evaluated the mRNA levels of these biomarkers in whole blood cultures from volunteers who maintained the same diagnosis between recruitment and the six or 12-month appointment

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The usual daily recommended amounts of cyanocobalamin, vitamin B12 either through dietary intake or supplementation should be taken during pregnancy (see Dosage)