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Modern whole-body cryotherapy emerged in Japan during the 1970s when Professor Toshiro Yamauchi observed that rheumatoid arthritis patients returning from winter mountain holidays showed improved symptoms

J Learn Disabil

Results announced in December 2025 confirmed the Phase 2 findings at a longer timepoint (Lilly Press Release, Dec 2025): The 28.7% weight loss at 68 weeks exceeds both semaglutide (~15% in STEP trials) and tirzepatide (~22.5% in SURMOUNT trials) at similar timepoints

17 A new phase 2, placebo-controlled, randomized clinical trial will analyze the effect of lipoic acid on brain atrophy in 118 participants with SPMS
