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Moreover, aged mice have been shown to be more susceptible to the release of proinflammatory cytokines and DNA oxidation from the same CS exposure than young mice with proper robust adaptive responses [16]
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ECHS1, which has been first detected in ox heart and liver, catalyzes the conversion of trans-2-enoyl-CoA thioesters to 3-L-hydroxyacyl-CoA thioesters and is responsible for the second step of fatty acid -oxidation (FAO) [21, 22]
The GCL enzyme is a heterodimer composed of a catalytic and a regulatory subunit
doi: 10.1016/j.stem.2016.06.001 13 VeltenLStoryBAHernandez-MalmiercaPRaffelSLeonceDRMilbankJet al
