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The development of nanotechnology-based formulations, such as liposomes and nanophytosomes, has shown great promise in enhancing the solubility, stability, and brain bioavailability of these compounds, thereby maximizing their neuroprotective effects in ASD ( However, it is important to note that curcumin has also been identified as a PAINS, exhibiting behaviors such as redox cycling, metal chelation, aggregation, and fluorescence interference that can artificially inflate its apparent bioactivity in vitro ( Weight of evidence: Overall evidence is LowModerate : robust mechanistic plausibility and diverse preclinical benefits

14 DiNicolantonioJ

The curcumin analog EF24 targets NF-B and miRNA-21, and has potent anticancer activity in vitro and in vivo

128 In a placebo-controlled trial with 96 participants, 1 gram of curcumin daily for four weeks reduced itching and increased quality of life in men with chronic dermatitis due to toxic mustard exposure

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