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They are stable at higher temperatures and under acidic conditions, which may be required for conjugation to radionuclides

2) This study performed by researchers Heffernan et al explored the chronic and acute metabolic effects of AOD9604 in several mouse models, including lean C57BL/6J, ob/ob, WT, and 3-KO mice

Studies in mice confirmed that animals lacking beta-3 receptors showed no response to AOD-9604, proving this pathway is essential to the mechanism

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Peripheral neuropathy may take 36 months to improve, and some patients experience incomplete recovery, particularly if treatment was delayed