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A noticeable color change, particularly a fading of the pink/red hue from Vitamin B12, is a strong indicator of degradation

doi: 10.1002/1097-0142(19840915)54:6 3.0.co;2-1
doi: 10.1016/j.bbrc.2014.04.053 91

Savic D, Hodson L, Neubauer S, et al
