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Irreversible thiol oxidation in carbonic anhydrase III: protection by S-glutathiolation and detection in aging rats

GPx1-deficient endothelial cells were more susceptible to the effects of inflammatory mediators, such as TNF (tumor necrosis factor ) and lipopolysaccharide, than cells with normal levels of GPx1

The authors reported a mildly yet significantly higher 3-year cumulative incidence of severe adverse events in patients receiving methotrexate versus placebo (0.13, 95% CI: 0.120.15 versus 0.10, 95% CI: 0.080.11)

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Chicago, IL: Contemporary Books.