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The tissue-specific distribution of beta-3 receptors (concentrated in fat tissue) further enhances selectivity
5-amino-1MQ showed concentration-dependent inhibition of NNMT in fully differentiated adipocytes that could be fit to a 3-parameter sigmoidal dose-response curve with a calculated EC 50 = 2.3 +/ 1.1 M (Figures 2E, 2F
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