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Said combination has a synergic effect useful in the treatment of different physiological or phatological conditions accompanied by a muscular hypoexcitability and/or hypocontractility such as denutrition, pre-diabetic and diabetic conditions, hemodialyses, hyperlipemia, cardiopathy, hepatic insufficiencies.

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The reaction was highly selective for cyclization at the GSH tag, enabling the combination of GST-catalyzed ligation with native chemical ligation to generate a large 40-residue peptide macrocycle.

2) Check the ingredient list for potential allergens

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