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Nature 453, 657661 (2008)

PMID 33858992

Lactate and pyruvate are transported by monocarboxylate transporters (MCTs) and mitochondrial pyruvate carriers (MPCs) in the cell membrane and mitochondrial membrane

However, etiologic factors that lead to chronic liver diseases (CLDs), such as alcohol-related liver disease, nonalcoholic fatty liver disease, viral hepatitis, and primary biliary cholangitis, can all affect the brain through mechanisms independent of liver failure/dysfunction triggering [44,45,46,47]

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