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However, iPSCs are increasingly being used to model HD and provide a promising avenue to characterize trafficking defects [217,218,219,220]

[] About 10% of patients with acute-on-chronic liver failure and more than 30% of patients with advanced stages of acute-on-chronic liver failure develop into respiratory failure

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It has been shown that simple allometric scaling for mAbs that exhibit linear PKs in monkeys can accurately predict human PK within a twofold range.16 However, for mAbs that display nonlinear PK, due to targetmediated drug disposition, allometric scaling results in an overestimation of exposure when below targetsaturating concentrations