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10.1016/j.ajpath.2017.07.020 13 BolignanoD.CernaroV.GembilloG.BaggettaR.BuemiM.D'ArrigoG

Evidence shows that inhibiting the TGF- pathway with small-molecule inhibitors, neutralizing monoclonal antibodies, or downstream Smad blockade effectively reverses EMT, suppresses fibroblast-to-myofibroblast differentiation, and thereby modulates aberrant lung repair and fibrotic progression

While it is unlikely that topical application could increase the systemic levels of vitamin A substantially (hypervitaminosis A), a modest systemic elevation of vitamin A levels by the topical treatment may have affected the small warts on the left hand

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Additionally, administration of a clinically available GHR antagonist (pegvisomant) attenuates the fall of whole-body energy expenditure of food-deprived mice, similarly as seen by leptin treatment