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doi: 10.1038/scientificamerican0809-54

Taken together, APS functions as an anti-inflammatory agent in animals and exerts its anti-inflammation mainly by inhibiting NF-B signaling pathways and reducing expression of pro-inflammatory cytokines

For example, esculetin (20-60 mg/kg) can inhibit the production of inflammatory factors such as IL-1, IL-6, TNF-, C-C motif chemokine ligand 2 and iNOS in Escherichia coli-induced sepsis mice by inhibiting the NF-B and STAT1/STAT3 signaling pathways (95)

GMP-grade workflows require scalable purification technologies such as tangential flow filtration (TFF), membrane ultrafiltration/diafiltration, chromatographic fractionation, and sterile 0.22 m filtration to ensure consistent removal of organic contaminants