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369,370 Although no cases of bi-allelic homozygous OPA1 mutations have been reported, bi-allelic compound heterozygous mutations have been observed and are associated with ADOA-plus (or Behr syndrome), 371,372 which presents with additional multisystemic features beyond the optic neuropathy

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Once inside the cell, the facilitative transporters located in the luminal membranes mediate export from the endothelial cell to the blood

This inhibition in growth and yield under combined stress is attributed to the negative interactions between heat and drought, with the effects becoming additive when combined 20