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Ann Neurol 24:446449 Malessa S, Leigh PN, Bertel O, Sluga E, Hornykiewicz O (1991) Amyotrophic lateral sclerosis: glutamate dehydrogenase and transmitter amino acids in the spinal cord

The CD44v9 is active though increasing the intracellular levels of glutathione (GSH) when combined with the functional subunit of the cystine/glutamate transporter (xCT), resulting in cellular protection from reactive oxygen species (ROS) and oxidative stress, which is one of the distinct characteristics of CSCs [72, 73]

Moreover, it also reduces the protein levels of PI3K, Akt, mTOR, and Ras, Raf, and p-ERK, indicating that H 2 S may regulate human TNBC cells through dual targeting of the PI3K/Akt/mTOR and Ras/Raf/ERK signaling pathways 369 (Fig

Cancer Cell (2019) 35:83049

10.1021/nn405383a 34 KamelR.El MorsyE