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doi: 10.1074/jbc.275.18.13259

Prolonged Inactivity Long periods without physical activity, such as long car rides or air travel, increase susceptibility to venous thrombosis and pulmonary embolism in people with other risk factors

caspase-mediated cleavage inactivates PARP, thereby terminating cellular DNA repair functions and ensuring the irreversibility of the apoptotic program), DNA-dependent protein kinase (DNA-PK) (similar to PARP, DNA-PK is another critical protein involved in DNA double-strand break repair

[99] It has been suggested that the relative affinity of dsDNA antibodies from SLE patients for LJP-394 may impact their responses to the drug, and patients with high-affinity antibodies to LJP-394 experience a reduction in affinity after four months of weekly treatment

Clin Microbiol Inf 3:432439 Navarro J, Rainisio M, Harms HK, Hodson ME, Koch C, Mastella G, Strandvik B, McKenzie SG (2001) Factors associated with poor pulmonary function: cross-sectional analysis of data from the European Epidemiologic Registry of Cystic Fibrosis (ERCF)