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9 , e107060 (2014)

[DOI] [PubMed] [Google Scholar] 21.Papi A., Di Stefano A.F.D., Radicioni M

Due to the presence of hydrophobic amino acids, the release of A fragments initially leads to the spontaneous aggregation of A monomers into soluble A oligomers, followed by aggregation of the oligomers to form insoluble protofibrils (Hayden and Teplow, 2013)

Abstract Background The insulin/IGF-1 signaling pathway has a major role in the regulation of longevity both in Caenorhabditis elegans and mammalian species, i.e., reduced activity of this pathway extends lifespan, whereas increased activity accelerates the aging process

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