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Furthermore, DEHP may increase TSHR expression with the subsequent activation of downstream effectors of the phosphatidylinositol-3 kinase (PI3K)/AKT and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathways, which regulate cell growth, differentiation, and apoptosis and whose genetic alterations have been associated with the onset and progression of TC [144,145,146]

Therefore, quercetin can be considered a proper treatment for PCOS, especially if its impact on methylation is precisely studied

Kleinberg, D

Cisplatin is a platinum-based chemotherapy drug that was approved by the FDA in 1978 despite its harsh side effects of inducing organ damage (including the liver and kidneys) [299], through oxidative metabolism via CYP2E1 and CYP4A11 [300]