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e Silva and colleagues (68) propose that tumor necrosis factor- (TNF-) and IL-6 are the two major cytokines upregulated in COVID-19 that directly affect brain physiology

As a chemokine receptor expressed on microglia surfaces, Cx3cr1 deficiency impairs normal microglial regulation

Dopaminergic transmission is the direct target of a number of drugs of abuse, and is secondarily affected by virtually all abused drugs (reviewed in Volkow and Morales, 2015)

A combination of the CFTR corrector Lumacaftor and the potentiator Ivacaftor has been approved for the treatment of patients bearing the most common F508del-CFTR mutation in homozygosis in spite of modest clinical benefits

Tumors arising in serine-limited environments can acquire a fitness advantage by upregulating serine synthesis pathway enzymes, implying that inhibition of serine metabolism can only be achieved by both PHGDH inhibition and dietary restriction of serine
