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First, FOXO4 localizes predominantly in the cytoplasm of normal Leydig cells, as shown by both our in vitro and in vivo findings, while it is within the nucleus that FOXO4-DRI interferes with the FOXO4-p53 interaction [24]

Hypothyroidism: Effects of Vitamin D and B12 Deficiency Learn how vitamin D and B12 deficiencies exacerbate hypothyroidism

The two are connected

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