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The expression level of PARP-1 in breast cancer, ovarian cancer, endometrial cancer, lung cancer, skin cancer and non-Hodgkins lymphoma is elevated compared to normal tissues, thus establishing a strong association between parthanatos and these cancers (Harraz et al., 2008

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Moreover, a reduced GSH synthesis could also be a contributory factor for the GSH depletion, as it has been documented in cirrhotic livers [32]