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556 Consequently, researchers believe that HIF-1 may serve as a mechanism for cells to rapidly respond to acute hypoxia, whereas HIF-2 may be more relevant in chronic hypoxic responses

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doi: 10.1172/jci84431 126 JiYLiXYaoXSunJYiJShenYet al

Mitochondria can also take up extracellular iron ions and transport them into their interior via specific transporters, where they are used for heme synthesis or stored in mitochondrial ferritin