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In macrophages, different Clostridium derivatives exert multifarious effects: CB -derived EVs inhibit the MAPK/NF-B pathway through the miR-199a-3p-map3k4 axis, inducing M2 polarization (8486)

Ksiazkiewicz M, Gottfried E, Kreutz M, Mack M, Hofstaedter F, Kunz-Schughart LA

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The surface modification of blood exosomes with transferrin-conjugated superparamagnetic nanoparticles via interaction with the transferrin receptor, with L17E endosomolytic peptides (IWLTALKFLGKHAAKHEAKQQLSKL) via electrostatic interactions, and with cholesterol-conjugated miR-21 inhibitor by anchoring to the lipid membrane increased tumor accumulation and drug delivery and enabled efficient endosomal escape 40

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