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From a genetic standpoint, methylation can cause genes to either express, or become "silent"

In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

Dose Adjustment Based on Response: Individual response to AOD-9604 varies based on factors including baseline body composition, metabolic health, diet quality, exercise habits, and genetic factors