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Similar content being viewed by others Introduction Fatty acid synthase (FASN) is a multienzyme protein that catalyzes the synthesis of fatty acids (mainly the long-chain saturated fatty acid palmitate) from acetyl-CoA and malonyl-CoA in the presence of nicotinamide adenine dinucleotide phosphate reduced form (NADPH) 1

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This then consumes glutathione for its conjugation, resulting in depletion of glutathione stores

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