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PMC 5573066

233 Sodium-glucose cotransporter-2 (SGLT2) inhibitors are commonly used for type 2 diabetes treatment, and in recent years, SGLT2 inhibitors canagliflozin has been shown to suppress IL-6 and IL-1 levels and MPO enzyme activity in the colon of UC rats by downregulating the expression of NF-B p65, thereby reducing colonic inflammatory cell infiltration and oxidative stress

Do not use for diagnostic or therapeutic purposes or as medical device

It has been tested in six clinical trials involving around 900 test subjects and has been determined by an appropriately qualified GRAS panel of experts to be Generally Recognized As Safe (GRAS) under conditions of intended uses of AOD9604 in foods [1]

Philp, D., Goldstein, A