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doi: 10.1371/journal.pone.0044861
Most patients report improvements in skin texture, firmness, and hydration within 4-8 weeks

For a 5 mg/mL concentration, add 2.0 mL

Although diet and lifestyle are major influences, your genetics are thought to be responsible for between 45-60% of the variance in plasma (blood) homocysteine levels in normal adults

Foster ZSL, Sharpton TJ, Grnwald NJ
