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Finally, while the review highlights the role of tumor-microenvironment interactions in DTP persistence, the dynamic complexity of these ecosystems, including spatial and temporal variations in immune cell infiltration, stromal remodeling, and metastatic niches, is not fully elucidated, leaving critical gaps in understanding context-specific resistance mechanisms

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This is especially true when mycotoxins stimulate mast cell and microglial activation, two immune pathways that can profoundly impact brain function 25
