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McGarrity S, Anuforo O, Halldorsson H, Bergmann A, Halldorsson S, Palsson S, Henriksen HH, Johansson PI, Rolfsson O (2018) Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification

10.1016/j.plipres.2007.07.001 47 DevineD

Catalysis of GPx is essentially following three distinct redox modifications of the Se at the center of the active site, in a triad of selenocysteine, glutamine, and tryptophan, which reduces GSH to GSSG [14, 19]

The repercussions of GSH depletion extend further, as it compromises the functionality of GPX4

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