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[DOI] [PMC free article] [PubMed] [Google Scholar] 162.Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S

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Findings observed in laboratory investigations should not be interpreted as evidence of therapeutic efficacy, clinical utility, or approved medical applications

A randomized controlled trial in coronary artery disease patients revealed that 12-week aerobic exercise (150 min/week, it is the minimum recommended by the ACSM in reference to exercise) increased Smyd1 (SET And MYND Domain Containing 1) expression by 1.8-fold in myocardial biopsy samples, accompanied by a 37% reduction in plasma malondialdehyde (MDA) levels and a 4.2% improvement in left ventricular ejection fraction (LVEF) (Hambrecht et al., 1993)
