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Evidence for and against some of these mechanisms can be found here (Decoursey and Ligeti, 2005)

Estrogen also plays a role in appetite, interacting with two hunger-modulating hormones

It is also used in comparative receptor binding studies examining IGF-1R versus insulin receptor (IR) cross-reactivity and downstream signal divergence

doi: 10.1016/j.heliyon.2019.e02029

This review will present the evidence for metabolic coupling as framed by the ANLS hypothesis, while acknowledging and examining these ongoing methodological and interpretive debates where relevant