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The main effect of endogenous GIP regarding weight is primarily on adipose tissue, where it promotes positive energy balance

This process is a multifaceted and intricate regulatory mechanism, with multiple pathways mediating mitophagy demonstrating parallelism or redundancy to preserve the equilibrium between mitochondrial homeostasis and the mitochondrial quality control system (Figure 3)

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Overall, omega-3 fatty acids, due to their anti-inflammatory, anti-catabolic properties and improved nutritional status, show potential to alleviate cancer cachexia and may help reduce muscle wasting, stabilize body weight, and improve patients' quality of life

Overall, the MM/PBSA results suggest that all three compounds have the capacity to bind to the receptor UDP-N-acetylmuramyl-tripeptide synthetase with favorable free energy
